Published 1989
| Version v1
Journal article
Radioiodination via vinylstannylated alkylating agents
Creators
- 1. Johns Hopkins Univ., Baltimore, MD (USA). Dept. of Radiology
- 2. Johns Hopkins Univ., Baltimore, MD (USA). Dept. of Environmental Health Sciences
Description
ρ-Toluenesulfonate esters of (E)- and (Z)-3-(tri-n-butylstannyl)-2-propen-1-o1 readily react with nucleophiles to give vinylstannanes which are substrates for rapid, efficient and stereospecific radioiododestannylation at the no-carrier-added level. This general approach is illustrated by syntheses of iodinated spiperone analogs for studies of dopamine D2 receptors. (author)
Additional details
Publishing Information
- Journal Title
- Tetrahedron Letters
- Journal Volume
- 30
- Journal Issue
- 28
- Series
- Tetrahedron Lett.
- Journal Page Range
- 3613-3616
- ISSN
- 0040-4039
- CODEN
- TELEA
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 21030704
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ALKYLATING AGENTS; CHEMICAL PREPARATION; DOPAMINE; IODINE 123; IODINE 125; LABELLING; LIGANDS; LIQUID COLUMN CHROMATOGRAPHY; RADIOPHARMACEUTICALS; STANNATES
- Descriptors DEC
- AMINES; ANTIMITOTIC DRUGS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENT; BETA DECAY RADIOISOTOPES; CARDIOTONICS; CARDIOVASCULAR AGENTS; CHROMATOGRAPHY; DAYS LIVING RADIOISOTOPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; OXYGEN COMPOUNDS; PHENOLS; POLYPHENOLS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SEPARATION PROCESSES; STEROIDS; SYMPATHOMIMETICS; SYNTHESIS; TIN COMPOUNDS
Optional Information
- Contract/Grant/Project number
- Grant CA32845; CA09199