Study of UV-radiation-induced DNA repair in mouse spleen cells after whole-body 60Co-γ-irradiation
Creators
- 1. Gosudarstvennyj Inst. Radiobiologii i Radiogigieny F. Zholio-Kyuri
- 2. Semmelweis Orvostudomanyi Egyetem, Budapest (Hungary)
Description
A study was made of the UV-radiation-induced DNA repair, in the presence of hydroxyurea, in mouse spleen cells isolated after whole-body 60Co-γ-irradiation. In order to separate native DNA from that containing singlestranded breaks BDN-cellulose technique was applied. It was established that γ-radiation affects the UV-radiation-induced repair synthesis in mouse spleen cells. Not long after γ-irradiation (6h, 24h and 3 days), the UV-radiation-induced incorporation of 3H-thymidine in DNA, in the presence of hydroxyurea, is decreased as compared to the control. However, at later times (after a fortnight), the UV-induced unscheduled DNA synthesis was 50% as high as that in the control. After three weeks, the UV-induced DNA repair synthesis in exposed cells was the same as in the controls
Additional details
Additional titles
- Original title (Russian)
- Исследование UF-индуцированной репарации DNK в клетках селезенки мышей после общего облучения γ-лучами
Publishing Information
- Journal Title
- Radiobiologiya
- Journal Volume
- 20
- Journal Issue
- 4
- Series
- Radiobiologiya.
- Journal Page Range
- 508-513
- ISSN
- 0033-8192
INIS
- Country of Publication
- Russian Federation
- Country of Input or Organization
- USSR
- INIS RN
- 12607403
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL REPAIR; BIOSYNTHESIS; COBALT 60; DNA; MALES; MICE; RADIATION DOSES; RESPONSE MODIFYING FACTORS; SPLEEN; TIME DEPENDENCE; ULTRAVIOLET RADIATION; WHOLE-BODY IRRADIATION
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL RECOVERY; BODY; COBALT ISOTOPES; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; NUCLEIC ACIDS; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIATIONS; RADIOISOTOPES; RODENTS; SYNTHESIS; VERTEBRATES; YEARS LIVING RADIOISOTOPES
Optional Information
- Notes
- For English translation see the journal Radiobiology (USA).