Published September 1981
| Version v1
Journal article
The effect of lactate on the radiation response of CHO-K1 cells in culture
Creators
- 1. Dublin Inst. of Technology (Ireland)
- 2. Saint Luke's Hospital, Dublin (Ireland)
Description
The radiobiological effect of lactate is described. Prolonged incubation of CHO- K1 cells over a wide range of lactate concentrations sensitized them to subsequent irradiation. Survival curves indicated that the size of the shoulder was reduced. Short treatment times resulted in a radioprotective effect and an increase in the survival curve slope. Lactate levels used were within physiological limits and are therefore discussed in relation to their possible implications in radiobiology and radiotherapy. (author)
Additional details
Publishing Information
- Journal Title
- Int. J. Radiat. Biol. Relat. Stud. Phys., Chem. Med.
- Journal Volume
- 40
- Journal Issue
- 3
- Series
- Int. J. Radiat. Biol. Relat. Stud. Phys., Chem. Med.
- Journal Page Range
- 283-291
- ISSN
- 0020-7616
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 13653378
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ANIMAL CELLS; BIOLOGICAL RADIATION EFFECTS; HAMSTERS; IN VITRO; INCUBATION; LACTATES; LACTIC ACID; OVARIES; RADIOSENSITIVITY; RESPONSE MODIFYING FACTORS; SURVIVAL CURVES; TIME DEPENDENCE
- Descriptors DEC
- ANIMALS; BIOLOGICAL EFFECTS; BODY; CARBOXYLIC ACID SALTS; CARBOXYLIC ACIDS; FEMALE GENITALS; GONADS; HYDROXY ACIDS; MAMMALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIATION EFFECTS; RODENTS; VERTEBRATES