Development of nanostructured polymeric excipient based on polyvinylpyrrolidone/polycaprolactone and nano clay applied to isoniazid and caffeine

In this study, PVP/PCL (3:1) systems were prepared via solution, incorporating sodium nanoclay at concentrations of 1, 3 and 5% (m/m) and spray drying. Caffeine and isoniazid were incorporated into the nanocomposites with a focus on the analysis of molecular mobility and crystallinity for modulation of modified drug release. The systems were characterized by X-ray diffraction (XRD) and time domain nuclear magnetic resonance (TD-NMR).The results indicate that the manipulation of the drug/clay ratio is a viable alternative for the modulation of drug release. (author)