Synthesis, stereochemistry, and pharmacology of some new (3-quinuclidyl) diheteroaryl-and aryl heteroaryl carbinols

The investigation of the antisecretory and antiulcer activity was performed on hybrid male rats. The influence of the compounds on the gastric secretory function was determined by the method of Shai in the modification of Meyer. Gastric ulcers were induced in the rats by the single ip application of 30 mg of histamine. The data obtained indicate that compound (Ic.HCI) shows antisecretory action. Analysis relating to the chemical shifts of protons induced by Eu (DPM)3 in the difuryl and dithienyl derivatives indicates that the other two substituents at c9 can be determined correspondingly from the concurrence of difference of the signs of the shifts induced for the rotons of the given substituent