NMR studies of myocardial energy metabolism and ionic homeostasis during ischemia and reperfusion
Description
In this study several aspects of myocardial energy metabolism and ionic homeostasis during ischemia and reperfusion were investigated in isolated perfused rat hearts, regionally ischemic rabbit hearts, and ex vivo human donor hearts during long term hypothermic cardioplegia. Phosphorus-31 nuclear magnetic resonance (31P NMR) spectroscopy was used as a powerful tool to non-destructively follow the time course in changes in intracellular high-energy phosphates, (creatine phosphate and ATP), inorganic phosphate, and pH. In addition, changes in intracellular free magnesium were followed during ischemia and reperfusion. Sodium-23 (23Na) NMR spectroscopy was used to study intracellular sodium during ischemia and reperfusion and during calcium-free perfusion. (author). 495 refs.; 33 figs.; 11 tabs
Availability note (English)
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21027783.pdf
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Additional details
Additional titles
- Subtitle (English)
- A basis for protective mechanisms
Publishing Information
- Imprint Pagination
- 159 p.
- Report number
- INIS-mf--12522
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- Netherlands
- INIS RN
- 21027783
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Thesis
- Descriptors DEI
- ISCHEMIA; METABOLISM; MYOCARDIUM; NMR SPECTRA; PERFUSED ORGANS; PHOSPHORUS 31
- Descriptors DEC
- ANEMIAS; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; DISEASES; HEART; HEMIC DISEASES; ISOTOPES; LIGHT NUCLEI; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PHOSPHORUS ISOTOPES; SPECTRA; STABLE ISOTOPES; SYMPTOMS
Optional Information
- Notes
- Includes summary in Dutch.