Influence of solute size on the thermodynamic parameter of transfer of a nonpolar hydrophobic solute from gas to water or from light to heavy water

Using the modified versions of the scaled particle theory amended by Stillinger, the influence of nonpolar solute size on its thermodynamic parameters of transfer from gas to water or from light to heavy water has been investigated. In the first case it is found that the process is dominated by an entropy contribution at small solute size and an enthalpy contribution at larger size. In the second process the increase in solute size also results in a change in the sign of the free energy and enthalpy of transfer, which is supported by experimental data on bulky solutes, such as adamantanemethanol or sodium adamantanecarboxylate