Published 1986 | Version v1
Journal article

Water and exchangeable sodium in Goldblatt two-kidney, two-clip hypertensive rats

Description

Exchangeable 22Na (ExNa), total body water (TBW) and the inulin space (InSp) were determined in two-kidney, two-clip (2K-2C) hypertensive and sham operated (normotensive) control rats 6-8 weeks after surgery. TBW (ml/kg lean body weight) was the same in hypertensive and sham rats. In contrast, ExNa (mEq/kglbw) and InSp (ml/kglbw) significantly increased (p less than 0.01) in rats whose hypertension did not exceed 170 mmHg. Consequently, sham, moderate hypertensive (less than 170 mmHg) and severe hypertensive (less than 170 mmHg) animals showed equal TBW but differed in body water distribution in that moderately hypertensive animals displayed a redistribution of water in favor of the extracellular space

Additional details

Publishing Information

Journal Title
Clin. Exp. Hypertens., Part A: Theory Pract.
Journal Issue
no.8
Series
Clin. Exp. Hypertens., Part A: Theory Pract.
ISSN
0730-0077
CODEN
CEHAD