Quantitative analysis of survival rate after syngeneic and semisyngeneic bone marrow transplantation: the correlation between the protective effect and capacity of induction of a secondary disease with distinctions in the main locus of histocompatibility

The protective effect of bone marrow (BM) with both syngeneic and semisyngeneic transplantation is an exponential function of the number of transplanted cells. The regression coefficient in the logarithmic equation represents a fraction of hemopoiesis repair units (HRU). The quantitative analysis of the remote death of recipients of the parents' BM shows that the secondary disease (SD) is caused by other than HRU cells which is in agreement with the data obtained by other methods. The fraction of BM cells that induces SD is lower than the fraction of HRU. This helps to find an optimum BM dose range within which the risk of the SD - induced death is minimized