Published March 1977
| Version v1
Journal article
Comparative effectiveness of Ca-DTPA, desferrioxamine B and their combination in removing transuranium elements from rats
Creators
- 1. Kernforschungszentrum Karlsruhe (Germany, F.R.). Inst. fuer Strahlenbiologie
Description
Prompt chelation therapy after incorporation of 239Pu, 241Am, 242Cm and 252Cf, respectively, was tested in rats. For 239Pu, especially in the bone, desferrioxamine-B-methane sulfonate (DFOA) is superior to calcium diethylenetriaminepentaacetate (Ca-DTPA): the combination of both is equally effective as DFOA, but the presence of Ca-DTPA prevents translocation of 239Pu to the kidneys occurring with DFOA alone. DFOA further decreases retention of 252Cf in the liver, but it does not affect tissue retention of 241Am and 242Cm. (author)
Additional details
Identifiers
Publishing Information
- Journal Title
- Health Physics
- Journal Volume
- 32
- Journal Issue
- 3
- Series
- Health Phys.
- Journal Page Range
- 155-157
- ISSN
- 0017-9078
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 8321546
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- AMERICIUM 241; AMINES; CALCIUM COMPOUNDS; CALIFORNIUM 252; COMPARATIVE EVALUATIONS; CURIUM 242; DECONTAMINATION; DTPA; KIDNEYS; LIVER; PLUTONIUM 239; RADIONUCLIDE KINETICS; RATS; RETENTION; SKELETON; SULFONATES
- Descriptors DEC
- ACTINIDE NUCLEI; ALKALINE EARTH METAL COMPOUNDS; ALPHA DECAY RADIOISOTOPES; AMERICIUM ISOTOPES; AMINO ACIDS; ANIMALS; BODY; CALIFORNIUM ISOTOPES; CARBOXYLIC ACIDS; CHELATING AGENTS; CLEANING; CURIUM ISOTOPES; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; EVEN-EVEN NUCLEI; EVEN-ODD NUCLEI; GLANDS; HEAVY NUCLEI; ISOTOPES; KINETICS; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; PLUTONIUM ISOTOPES; RADIOISOTOPES; RODENTS; VERTEBRATES; YEARS LIVING RADIOISOTOPES
Optional Information
- Notes
- Updated automatically by Metadata and Full-Text Enrichment Agent