Published 1975
| Version v1
Report
Open
Gamma irradiation of uridine and uridylic acid in aerated aqueous solutions: identification of the major product
Creators
Description
The major product of uridine gamma irradiation in aerated aqueous solution (10-3M, pH approximately 6) has been identified: N-(β-D-ribofuranosyl)-formamide. Thin layer silica gel chromatography and spectroscopic methods (mass spectrometry, NMR, IR, optical rotation) enabled to isolate and characterize this product. It may be assumed that this substance resulted from the hydrolytic degradation of unstable hydroxy-hydroperoxides. It was also prepared by uridine oxydation with pertrifluoracetic acid. A similar major compound in the radiolysis of uridylic acid has been found
Abstract (French)
Le produit majeur d'irradiation gamma de l'uridine en solution aqueuse aeree (10-3M, pH approximativement 6) a ete identifie au N-(β-D-ribofurannosyl) formamide Ce compose proviendrait de la degradation hydrolytique d'intermediaires hydroxyhydroperoxydes instables selon un processus comparable a celui mis en jeu dans le cas de la thymidine. Le derive formamide a ete isole sur couche mince de silice. Il a ete caracterise par des methodes spectroscopiques (spectrometrie de masse, RMN, IR, pouvoir rotatoire). La synthese du produit a ete realisee par oxydation de l'uridine avec l'acide pertrifluoracetique prepare in situ. Un compose analogue le N-(phosphoryl-5-β-D-ribofurannosyl) formamide a ete trouve apres irradiation gamma de de l'acide uridyliqueFiles
7259673.pdf
Files
(89.0 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:cbaeaca2fda3da0b315b19691ed80aca
|
89.0 kB | Preview Download |
Additional details
Additional titles
- Original title (French)
- Identification du produit majeur d'irradiation gamma de l'uridine et de l'acide uridylique en solution aqueuse aeree
Publishing Information
- Imprint Title
- Grenoble Fundamental Research Department
- Imprint Pagination
- p. 157-159.
- Report number
- CEA-N--1851
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 7259673
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Resource subtype / Literary indicator
- Progress Report
- Descriptors DEI
- AQUEOUS SOLUTIONS; GAMMA RADIATION; RADIOLYSIS; URIDINE; URIDYLIC ACID
- Descriptors DEC
- AZINES; CHEMICAL RADIATION EFFECTS; CHEMICAL REACTIONS; DECOMPOSITION; DISPERSIONS; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; HOMOGENEOUS MIXTURES; HYDROXY COMPOUNDS; IONIZING RADIATIONS; MIXTURES; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIATION EFFECTS; RADIATIONS; RIBOSIDES; SOLUTIONS; URACILS
Optional Information
- Notes
- Imprint:Departement de Recherche Fondamentale de Grenoble.;Bulletin semestriel no.8, 1975, 2. semestre.