Lethality from radiation pneumonitis and pulmonary fibrosis after combined alpha and beta irradiation of the lung
Creators
- 1. Lovelace Inhalation Toxicology Research Institute, Albuquerque, NM 87185
Description
Equal numbers of male and female F344/CRLLOV rats (total number = 288) 15 weeks of age were exposed by inhalation to the alpha emitter /sup 238/Pu, the beta emitter /sup 147/Pm, or to mixtures of both (in the same particle), inhaled in a matrix of fused aluminosilicate particles (FAP). Thirty-six control rats inhaled nonradioactive FAP. The experiment was conducted to validate the hazard function (HF) model for acute lethality after exposure to both high- and low-LET radiation. Pulmonary function measurements were carried out on surviving rats at 1.5 years after inhalation exposure. The HF model allows one to predict when a sublethal high-LET dose and a sublethal low-LET dose in combination should be lethal. Observed and predicted acute lethality dose-effect surfaces are compared and dose-effect surfaces for impaired pulmonary function are presented
Additional details
Publishing Information
- Publisher
- Radiation Research Society.
- Imprint Place
- Philadelphia, PA (USA)
- Imprint Title
- Thirty-fifth annual meeting of the Radiation Research Society (Abstracts)
- Journal Page Range
- p. 108.
Conference
- Title
- 35. annual meeting of the Radiation Research Society.
- Dates
- 22-26 Feb 1987.
- Place
- Atlanta, GA (USA).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 19049950
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S61: RADIATION PROTECTION AND DOSIMETRY;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- AGE GROUPS; BIOLOGICAL PATHWAYS; BIOLOGICAL RADIATION EFFECTS; DOSE-RESPONSE RELATIONSHIPS; FEMALES; FIBROSIS; INHALATION; INTERNAL IRRADIATION; LET; LETHAL IRRADIATION; LOW DOSE IRRADIATION; LUNGS; MALES; PHYSICAL RADIATION EFFECTS; PHYSIOLOGY; PLUTONIUM 238; PNEUMONITIS; PROMETHIUM 147; RADIATION DOSES; RADIATION EFFECTS; RATS
- Descriptors DEC
- ACTINIDE NUCLEI; ALPHA DECAY RADIOISOTOPES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BODY; DISEASES; ENERGY TRANSFER; EVEN-EVEN NUCLEI; HEAVY NUCLEI; INTAKE; INTERMEDIATE MASS NUCLEI; IRRADIATION; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PATHOLOGICAL CHANGES; PLUTONIUM ISOTOPES; PROMETHIUM ISOTOPES; RADIOISOTOPES; RARE EARTH NUCLEI; RESPIRATORY SYSTEM; RODENTS; SPONTANEOUS FISSION RADIOISOTO; VERTEBRATES; YEARS LIVING RADIOISOTOPES