Published 2022 | Version v1
Journal article

International consensus on the use of tau PET imaging agent 18F-flortaucipir in Alzheimer's disease

  • 1. Human Phenome Institute, Fudan University, 201203, Shanghai (China)
  • 2. Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, 310009, Hangzhou, Zhejiang (China)
  • 3. PET Center, Huashan Hospital, Fudan University, 200235, Shanghai (China)
  • 4. Department of Radiology and Radiological Science, Johns Hopkins Medicine, 21287, Baltimore, MD (United States)
  • 5. Department of Nuclear Medicine, Hospital Sant Pau, Autonomous University of Barcelona, 08025, Barcelona (Spain)
  • 6. Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, 650-0047, Kobe, Hyogo (Japan)
  • 7. Department of Nuclear Medicine, Seoul National University College of Medicine, 03080, Seoul (Korea, Republic of)
  • 8. Department of Radiology, Juntendo University Hospital, 113-8431, Tokyo (Japan)
  • 9. Diagnostic Department, University Hospitals of Geneva and NIMTlab, University of Geneva, Geneva (Switzerland)
  • 10. Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne (Switzerland)
  • 11. Department of Nuclear Medicine, Leipzig University Medical Center, Leipzig (Germany)
  • 12. National Center for Neurological Disorders & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, 200040, Shanghai (China)
  • 13. Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, 310007, Hangzhou (China)
  • 14. The College of Biomedical Engineering and Instrument Science of Zhejiang University, 310007, Hangzhou (China)
  • 15. Key Laboratory of Medical Molecular Imaging of Zhejiang Province, 310009, Hangzhou (China)

Description

Positron emission tomography (PET) with the first and only tau targeting radiotracer of 18F-flortaucipir approved by FDA has been increasingly used in depicting tau pathology deposition and distribution in patients with cognitive impairment. The goal of this international consensus is to help nuclear medicine practitioners procedurally perform 18F-flortaucipir PET imaging. A multidisciplinary task group formed by experts from various countries discussed and approved the consensus for 18F-flortaucipir PET imaging in Alzheimer's disease (AD), focusing on clinical scenarios, patient preparation, and administered activities, as well as image acquisition, processing, interpretation, and reporting. This international consensus and practice guideline will help to promote the standardized use of 18F-flortaucipir PET in patients with AD. It will become an international standard for this purpose in clinical practice.

Availability note (English)

Available from: http://dx.doi.org/10.1007/s00259-021-05673-w

Additional details

Identifiers

Publishing Information

Journal Title
European Journal of Nuclear Medicine and Molecular Imaging
Journal Volume
49
Journal Issue
3
Journal Page Range
p. 895-904
ISSN
1619-7070
CODEN
EJNMA6