Published 1989 | Version v1
Journal article Metadata-only

The Noah's Ark experiment: species dependent biodistributions of cationic 99mTc complexes

Creators

  • 1. Cincinnati Univ., OH (USA)

Description

The time dependent biodistributions of three related 99mTc complexes of 1, 2-bis(dimethylphosphino)ethane (DMPE) were evaluated in several animal species including humans: trans-[99mTcv(DMPE)2O2]+, trans-[99mTcIII(DMPE)2Cl2]+ and [99mTcI(DMPE)3]+. Imaging studies were performed in 10 animal species to evaluate these complexes as myocardial perfusion imaging agents. Animal models adequately predict the uninteresting behaviour of the Tc(V) cation in humans, predict to only a very limited extent the behaviour of the Tc(III) cation in humans and totally fail to predict the behaviour of the Tc(I) cation in humans. (U.K.)

Additional details

Publishing Information

Journal Title
Nuclear Medicine and Biology
Journal Volume
16
Journal Issue
3
Series
Nucl. Med. Biol.
Journal Page Range
191-232
ISSN
0883-2897
CODEN
NMBIE

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
21010280
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
BABOONS; CATS; COMPARATIVE EVALUATIONS; DOGS; GUINEA PIGS; HAMSTERS; HEART; MAN; MONKEYS; RABBITS; RADIOPHARMACEUTICALS; RATS; SCINTISCANNING; STRUCTURE-ACTIVITY RELATIONSHI; SWINE; TECHNETIUM COMPLEXES; TECHNETIUM 99; TISSUE DISTRIBUTION
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR SYSTEM; COMPLEXES; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISTRIBUTION; DOMESTIC ANIMALS; DRUGS; EVALUATION; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PRIMATES; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RODENTS; TECHNETIUM ISOTOPES; TRANSITION ELEMENT COMPLEXES; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Contract/Grant/Project number
Grant HL-21276