Nanocomposite foams based on flexible biobased thermoplastic polyurethane and ZnO nanoparticles as potential wound dressing materials

Highlights: • Biobased thermoplastic polyurethane/ZnO nanocomposite foams are fabricated by thermally induced phase separation method. • The produced foams possess suitable morphology to maintain proper environment at wound/dressing interface. • TPU/ZnO nnaocomposite materials are excellent in supporting hASC cells, their growth and proliferation. • The foams display low cytotoxic potential and are very effective against Gram positive and Gram negative bacteria. -- Abstract: In the present study biobased and soft thermoplastic polyurethane (TPU), obtained by polymerization from fatty acids, was used to produce TPU/ZnO nanocomposite foams by thermally induced phase separation method (TIPS). The produced foams were characterized and evaluated regarding their potential uses as wound dressing materials. The structure and morphology of the prepared flexible polymer foams with different content of ZnO nanofiller (1, 2, 5 and 10 wt% related to the polymer) were studied by Fourier transform infrared spectroscopy (FTIR) and Scanning electron microscopy (SEM). Highly porous nanocomposite structure made of interconnected pores with dimensions between 10 and 60 μm was created allowing water vapor transmission rate (WVTR) up to 8.9 mg/cm²·h. The TPU/ZnO foams, tested for their ability to support cells and their growth, showed highest cell proliferation for TPU nanocomposite foams with 2 and 5 wt% ZnO. Overall, the nanocomposite foams displayed a low cytotoxic potential (varied proportionally to the ZnO content) and good biocompatibility. All tested nanocomposite foams were found to be significantly active against biofilms formed by different Gram-positive (Enterococcus faecalis and Staphylococcus aureus) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria. Based on their behaviors, flexible TPU/ZnO nanocomposite foams can be considered for biomedical applications such as potential active wound dressing.