Published 1995
| Version v1
Journal article
Synthesis of H-3 labeled 5-fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)-1-piperazinyl]propyl]-1 H-indole, a serotonergic agent with potential antidepressant activity
Creators
- 1. Bristol-Myers Squibb Pharmaceutical Research Inst., Wallingford, CT (United States)
- 2. Lawrence Berkeley Lab., CA (United States)
Description
The title compound was prepared by the LiAlT4 reduction of 5-fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)-1-piperazinyl]-3-oxoprop yl]-1H-indole. The radiochemical purity of the product was 98.9% and the specific activity was calculated as 53.0 Ci/mmol from HPLC analyses and 55.6 Ci/mmol from 3H NMR measurements. (Author)
Additional details
Publishing Information
- Journal Title
- Journal of Labelled Compounds and Radiopharmaceuticals
- Journal Volume
- 36
- Journal Issue
- 8
- Journal Page Range
- p. 789-794.
- ISSN
- 0362-4803
- CODEN
- JLCRD4
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 27046968
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ANTIDEPRESSANTS; CHEMICAL PREPARATION; INDOLES; LABELLING; ORGANIC FLUORINE COMPOUNDS; PIPERAZINES; PYRIMIDINES; RADIOPHARMACEUTICALS; SEROTONIN; TRITIUM COMPOUNDS
- Descriptors DEC
- AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZAARENES; AZINES; AZOLES; CENTRAL NERVOUS SYSTEM AGENTS; DRUGS; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; HYDROXY COMPOUNDS; LABELLED COMPOUNDS; MATERIALS; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PSYCHOTROPIC DRUGS; PYRAZINES; PYRROLES; RADIOACTIVE MATERIALS; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; SYMPATHOMIMETICS; SYNTHESIS; TRYPTAMINES