Published January 1978 | Version v1
Journal article Metadata-only

Linear dose-response of acentric chromosome fragments down to 1 R of x-rays in grasshopper neuroblasts, a potential mutagen-test system

Creators

  • 1. Southern Methodist Univ., Dallas, Tex. (USA)
  • 2. Texas Univ., Dallas (USA). Southwestern Medical School

Description

Grasshopper-embryo neuroblasts have no spontaneous chromosome breakage; therefore they permit easy detection of agents that break chromosomes. An X-ray exposure of 1 R induces in them a detectable number of chromosome fragments. The dose-response of acentric fragment frequency fits a linear model between 0 and 128 R. Thus another cell type is added to those previously demonstrated to have no threshold dose for the induction of chromosome or gene mutations

Additional details

Identifiers

DOI
10.1016/0027-5107(78)90077-5;

Publishing Information

Journal Title
Mutation Research
Journal Volume
49
Journal Issue
1
Series
Mutat. Res.
Journal Page Range
55-60
ISSN
0027-5107

INIS

Country of Publication
Netherlands
Country of Input or Organization
Netherlands
INIS RN
9373523
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOASSAY; CELL CYCLE; CHROMOSOMAL ABERRATIONS; DISTRIBUTION FUNCTIONS; DOSE-RESPONSE RELATIONSHIPS; GRASSHOPPERS; MUTAGENS; MUTATION FREQUENCY; NERVE CELLS; THRESHOLD DOSE; X RADIATION
Descriptors DEC
ANIMAL CELLS; ANIMALS; ARTHROPODS; ELECTROMAGNETIC RADIATION; INSECTS; INVERTEBRATES; IONIZING RADIATIONS; MUTATIONS; PERFORMANCE TESTING; RADIATION DOSES; RADIATIONS; SOMATIC CELLS; TESTING

Optional Information

Notes
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