Quantitative analysis of prompt gamma ray imaging during proton boron fusion therapy according to boron concentration

Proton boron fusion therapy (PBFT) has been suggested as a novel radiation therapy technique and tumor monitoring technique for use during treatment. The PBFT method is a treatment technique based on the proton-boron fusion reaction. We confirmed the generation of a 719 keV prompt gamma ray after the proton-boron reaction. Thus, it was possible to develop a tumor-monitoring technique using a prompt gamma ray during PBFT. The main benefit of this prompt gamma ray imaging technique is a tumor monitoring method that does not require an extra dose during treatment, unlike computed tomography (CT) and X-ray. In our previous studies, a prompt gamma ray image was acquired with a specific boron concentration that was much higher than the clinically appropriate boron concentration range, so those studies were more conceptual in nature