Actual trends in treatment of cervical carcinoma

Cervical cancer is a common cancer in the female population caused by persistent infection with high-risk HPV types. As part of prevention, effective and safe HPV vaccination is available, which is fully covered by health insurance for children in the Slovak Republic. Treatment of early stages (FIGO IA, IB1. IB2. IIA1) is surgical (conization, trachelectomy, simplex hysterectomy, radical hysterectomy with lymphadenectomy) with an effort to avoid combined treatment with radiotherapy. For early tumors over 4 cm (FIGO IB3 and IIA2) and locally advanced diseases (FIGO IIB - IVA), radical chemoradiotherapy remains the basis of treatment. In metastatic stages, systemic treatment is primarily used - a combination of chemotherapy and biological treatment, to which immunotherapy is added. Immunotherapy significantly changes treatment procedures and we can expect that in the near future it will be used more and more in cervical cancer, and not only in metastatic disease. (author)