Published 1999 | Version v1
Miscellaneous Metadata-only

Relationship between transformation of human embryo lung cell and DNA strand break induced by γ-irradiation

Creators

  • 1. Institute of Radiation Medicine, Beijing (China)

Description

It was studied that effects of γ-irradiation on transformation and DNA strand break of human embryo lung cell by means of cell and molecular biology. The cell transformation appeared at 20th passage post 0.25-5.0 Gy γ-irradiation. The transformation was relative to doses and post-time of irradiation. DNA strand break was detected by NTA (nick translation assay in situ) in this report. The result indicated DNA strand break was arisen from γ-ray with different doses. DNA strand break also was relative to radiation doses as cell transformation. Correlation between DNA strand break and cell transformation was analysed. The analysis indicated that effect of cell transformation induced by radiation enhanced with increase of DNA strand brea. It was suggested that carcinogenesis by radiation is closely relative to DNA damage

Part of:
Proceedings of the national conference on radiation protection

Additional details

Publishing Information

Imprint Title
Proceedings of the national conference on radiation protection
Imprint Pagination
486 p.
Journal Page Range
p. 133-136

Conference

Title
National conference on radiation protection
Dates
16-20 Nov 1998
Place
Shenzhen (China)

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
36021365
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Conference, Non-conventional Literature
Descriptors DEI
CARCINOGENESIS; CELL TRANSFORMATIONS; COBALT 60; DNA; DOSE-RESPONSE RELATIONSHIPS; EMBRYONIC CELLS; GAMMA RADIATION; LUNGS; MAN; RADIATION INJURIES; RESPIRATORY TRACT CELLS; STRAND BREAKS
Descriptors DEC
ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; COBALT ISOTOPES; DISEASES; DNA DAMAGES; ELECTROMAGNETIC RADIATION; INJURIES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; NUCLEIC ACIDS; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PATHOGENESIS; PRIMATES; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RESPIRATORY SYSTEM; SOMATIC CELLS; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information