Effectiveness of premedication protocol using intravenous fentanyl to reduce pain associated with femoral artery closure device placement

Highlights: • We identified benefit of premedication with IV Fentanyl to reduce pain during femoral closure device placement. • All the patients treated with premedication protocol reported fair pain control compared with those who were not premedicated. • Treatment with premedication protocol was significantly associated with excellent pain control at closure device placement. -- Abstract: To test the effectiveness of a premedication protocol using intravenous bolus of 100 μg fentanyl to reduce pain associated with femoral artery closure device placement for neuro-endovascular procedures.