The effects of E838 on malignant transformation of mammalian cell induced by radiation
- 1. Chinese Academy of Medical Sciences, Tianjing (China). Beijing Union Medical College, Inst. of Radiation Medicine
Description
Objective: To study the effects of an anti-radiation medicine E838 on malignant transformation of mammalian cell induced by radiation. Methods: CHO and CHL cells were cultured in the RPMI 1640 medium with or without E838 and were irradiated with different doses of 137Cs γ-rays. The total number of colonies and type I, II and III malignant transformation foci were counted for each group three weeks after irradiation. Results: Statistic analysis indicated that the colony-forming rate of CHO cells in the groups cultured with E838 (1 μg/ml) was significantly higher than that of groups without E838 after irradiation with 3 Gy 137Cs γ-rays (P < 0.05). The transformation rate of the group with E838 was lower than that of the group without (P < 0.01). There was a similar tendency in CHL cells at the same irradiation dose, without statistical significance. Conclusion: In the proper concentration range E838 shows certain inhibitory effects on malignant transformation of mammalian cells induced by radiation
Additional details
Publishing Information
- Journal Title
- Chinese Journal of Radiological Medicine and Protection
- Journal Volume
- 21
- Journal Issue
- 1
- Journal Page Range
- p. 21-23
- ISSN
- 0254-5098
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 32044353
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ANIMAL CELLS; BIOLOGICAL RADIATION EFFECTS; CESIUM 137; COLONY FORMATION; GAMMA RADIATION; MAMMALS; RADIOINDUCTION
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; CESIUM ISOTOPES; ELECTROMAGNETIC RADIATION; INTERMEDIATE MASS NUCLEI; IONIZING RADIATIONS; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES