Published October 1996 | Version v1
Journal article Metadata-only

Labelled compounds of interest as antitumour agents. Pt. 5: Syntheses of [18O]-5-methylisoquinolinone and 1-(furan-2-yl-[18O]-methoxy)-5-methylisoquinoline

Creators

  • 1. Bath Univ., School of Pharmacy and Pharmacology, Bath (United Kingdom)

Description

Treatment of 2-methylcinnamic acid with H218O at 100oC under acidic condition leads to high incorporation of 18O by exchange. Methods have been developed for chemically and isotopically efficient conversion to the corresponding [carbonyl-18O] methyl ester, to [18O]-5-methylisoquinolinone (an inhibitor of DNA repair) and to 1-(furan-2-yl-[18O]-methoxy) -5-methylisoquinoline. (author)

Additional details

Publishing Information

Journal Title
Journal of Labelled Compounds and Radiopharmaceuticals
Journal Volume
38
Journal Issue
10
Journal Page Range
p. 935-940.
ISSN
0362-4803
CODEN
JLCRD4

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
29007191
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
ANTINEOPLASTIC DRUGS; CHEMICAL PREPARATION; LABELLED COMPOUNDS; LABELLING; OXYGEN 18; QUINOLINES
Descriptors DEC
AROMATICS; AZAARENES; AZINES; DRUGS; EVEN-EVEN NUCLEI; HETEROCYCLIC COMPOUNDS; ISOTOPES; LIGHT NUCLEI; NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; OXYGEN ISOTOPES; PYRIDINES; STABLE ISOTOPES; SYNTHESIS