Synthesis of [195mPt]-tetraplatin

(Trans d,1)-1,2-diaminocyclohexanetetrachloroplatinum(IV) (tetraplatin) is a second generation platinum antitumor agent which exhibits less toxicity than cisplatin and is effective in cell lines with acquired resistance to cisplatin. We previously reported the synthesis of tritium labelled tetraplatin which was utilized in both tissue culture and in vivo studies. Loss of the labelled diaminocyclohexane carrier moiety during the in vivo studies necessitated the synthesis of [195mPt]-tetraplatin from [195mPt]-potassium hexachloroplatinate as described herein. (author)