Published September 1993 | Version v1
Journal article Metadata-only

Radiation therapy of the nasopharyngeal carcinoma

Creators

  • 1. Department of Radiation Therapy, Center for Adult Diseases, Osaka (Japan)
  • 2. Department of Otolaryngology, Center for Adult Diseases, Osaka (Japan)

Description

Between September 1977 and December 1989, 89 consecutive patients of nasopharyngeal carcinoma were treated with radiation therapy. The study comprized of 66 males and 23 females; their ages ranged 17 to 80 years (mean 55 years). Five-years survival rates according to stage were as follows: stages I and II (n=10), 90%; stage III (n=10), 43%; stage IV (n=69), 47%. The important prognostic factors for predicting poor prognostic in this series, which were shown by stepwise proportional hazard (Cox) model, were the level of lactate dehydrogenase (LDH) and neck node involvement. LDH level also influenced nodal failure (p=0.0002) and distant metastatis (p=0.006). (orig.)

Abstract (German)

In der Zeit zwischen September 1977 und Dezember 1989 wurden 89 aufeinanderfolgende Faelle von Nasopharynxkarzinomen strahlentherapeutisch behandelt. Die Studie umfasste 66 maennliche und 23 weibliche Patienten im Alter von 17 bis 80 Jahren (Mittelwert 55 Jahre). Die nach Stadien geordneten Fuenf-Jahre-Ueberlebensraten betrugen 90% fuer die Stadien I und II (n=10), 43% fuer Stadium III (n=10) und 47% fuer Stadium IV (n=69). Die durch das proportionale Zufallsmodell von Cox schrittweise ermittelten wichtigsten Faktoren fuer eine schlechte Prognose waren der Lactatdehydrogenasegehalt (LDH) und der Befall der Halsknoten. Die LDH-Konzentration hatte auch Auswirkungen auf das Auftreten von Lymphknotenschaeden (p=0,0002) und Fernmetastasen (p=0,006). (orig.)

Additional details

Additional titles

Subtitle (English)
Treatment results and prognostic factors

Publishing Information

Journal Title
Strahlentherapie und Onkologie
Journal Volume
169
Journal Issue
9
Journal Page Range
p. 527-533.
ISSN
0179-7158
CODEN
STONE4

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
25018217
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
CARCINOMAS; EFFICIENCY; LACTATE DEHYDROGENASE; LYMPH NODES; METASTASES; NOSE; PATIENTS; PHARYNX; RADIOTHERAPY; SURVIVAL CURVES; SURVIVAL TIME
Descriptors DEC
ANIMALS; BODY; BODY AREAS; DEHYDROGENASES; DIGESTIVE SYSTEM; DISEASES; ENZYMES; FACE; HEAD; LYMPHATIC SYSTEM; MAMMALS; MAN; MEDICINE; NEOPLASMS; ORGANIC COMPOUNDS; ORGANS; OXIDOREDUCTASES; PRIMATES; PROTEINS; RESPIRATORY SYSTEM; THERAPY; VERTEBRATES