Published 1975
| Version v1
Journal article
Incapacity of 5-hydroxytryptophan against depression of antitumoral force of host animal which is induced by whole-body X-irradiation
Creators
- 1. Aichi Cancer Center, Nagoya (Japan)
- 2. National Inst. of Radiological Sciences, Chiba (Japan)
Description
The effect of L-5-hydroxytryptophan (L-5-HTP) against the depression of tumor-resisting power in host animal, which is induced by a whole body X-irradiation of 500R, was studied. Host animal and tumor cell used were LAF1 hybrid mouse and mastocytoma cell, respectively. The i.p. injected dose of L-5-HTP was 6.25 mg per mouse, which is most effective for protecting mice from radiation-induced hematopoietic death. In the experimental conditions, the agent was not effective to prevent the radiation-induced depression of tumor-resisting power of the animal
Abstract (French)
On a etudie l'effet protecteur du L-5-hydroxytryptophanne (L-5-HTP) vis-a-vis de la depression du pouvoir antitumoral de l'animal-hote induite par une irradiation corporelle totale de 500 R. Les animaux-hotes utilises etaient les hybrides F1 entre lignee C57L et A; les cellules tumorales sont une souche de mastocytome. La dose de la L-5-HTP i.p. utilisee etait de 6,25 mg par souris c'est-a-dire la dose la plus efficace pour proteger la souris de la mort hematopoietique induite par l'irradiation. Dans les conditions experimentales, ce radioprotecteur etait inefficace pour empecher la depression du pouvoir antitumoral de l'animalAdditional details
Additional titles
- Original title (French)
- Incapacite du 5-hydroxytryptophanne d'agir contre la depression du pouvoir antitumoral de l'animal-hote induite par une irradiation corporelle totale par les rayons X
Publishing Information
- Journal Title
- C. R. Soc. Biol.
- Journal Volume
- 169
- Journal Issue
- 2
- Series
- C. R. Soc. Biol.
- Journal Page Range
- 468-472
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 8281242
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; EXPERIMENTAL NEOPLASMS; HYDROXYTRYPTOPHAN; MICE; RADIOSENSITIVITY; WHOLE-BODY IRRADIATION; X RADIATION
- Descriptors DEC
- AMINO ACIDS; ANIMALS; BIOLOGICAL EFFECTS; CARBOXYLIC ACIDS; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; HYDROXY ACIDS; IONIZING RADIATIONS; IRRADIATION; MAMMALS; NEOPLASMS; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; VERTEBRATES