Published January 2002
| Version v1
Journal article
Synthesis and labeling of 5'-O-(4,4'-dimethoxytrityl)-2,3'-anhydrothymidine for [18F]FLT preparation
Creators
- 1. Tuebingen Universitaetsklinikum (Germany). Sektion Radiopharmazie, PET-Zentrum
Description
For in vivo measurement of DNA synthesis in the patient's tumour 3'-[18F]fluoro-3'-deoxythymidine (FLT) has been shown to be very promising. As a new labeling precursor 5'-O-(4,4'-dimethoxytrityl)-2,3'-anhydrothymidine (DMTThy) was chosen and an organic synthesis was developed including NMR and MS data for characterisation. The 18F-labeling of DMTThy can be performed within 30 minutes in radiochemical yields of almost 20% when using polar solvents such as DMF or DMSO and a temperature of 160 deg C. Hydrolysis is completed with 1N HCl at 50 deg C within 10 minutes without losses. (author)
Additional details
Publishing Information
- Journal Title
- Journal of Radioanalytical and Nuclear Chemistry
- Journal Volume
- 251
- Journal Issue
- 1
- Journal Page Range
- p. 55-58
- ISSN
- 0236-5731
- CODEN
- JRNCDM
INIS
- Country of Publication
- Hungary
- Country of Input or Organization
- Hungary
- INIS RN
- 33012953
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- CELL PROLIFERATION; CHEMICAL PREPARATION; CHEMICAL REACTION KINETICS; DNA; FLUORINE 18; IN VIVO; LABELLING; RADIOPHARMACEUTICALS; THYMIDINE; TUMOR CELLS
- Descriptors DEC
- ANIMAL CELLS; AZINES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; DRUGS; FLUORINE ISOTOPES; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NANOSEC LIVING RADIOISOTOPES; NUCLEI; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIOACTIVE MATERIALS; RADIOISOTOPES; REACTION KINETICS; RIBOSIDES; SYNTHESIS
Optional Information
- Notes
- 10 refs.