Study on the mechanism of radiation-induced MCP-1 expression in RAW264.7 macrophage cells
- 1. Korea Atomic Energy Research Institute, Jeongeup (Korea, Republic of)
Description
The purpose of this study was to investigate the expression mechanism of MCP-1 in gamma-irradiated RAW 264.7 macrophage cells. MCP-1 plays an important role in attracting monocyte to injured site at the early inflammation stage. However the production mechanism of MCP-1 by gamma-irradiation in RAW 264.7 macrophage cells was almost undiscovered. We found that MCP-1 was produced in RAW 264.7 macrophage cells by irradiation with 5 Gy. And these increases were attenuated by specific inhibitors treatment, such as NF-KB, JNK, ERK, JAK2, and Pyk2. These results indicate that radiation-induced MCP-1 production is mediated by MyD88-and TRIF-dependent pathways in RAW 264.7 macrophage cells. Furthermore, gamma-irradiation induced heme oxygenase-1 (HO-1) expression in RAW 264.7 macrophage cells. However this induction level was reduced before MCP-1 and IFN-β production
Additional details
Publishing Information
- Journal Title
- Journal of Radiation Industry
- Journal Volume
- 4
- Journal Issue
- 3
- Series
- 14 refs, 5 figs
- Journal Page Range
- p. 227-231
- ISSN
- 1976-2402
INIS
- Country of Publication
- Korea, Republic of
- Country of Input or Organization
- Korea, Republic of
- INIS RN
- 44038696
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- GAMMA RADIATION; INFLAMMATION; IRRADIATION; MACROPHAGES; RADIATIONS
- Descriptors DEC
- ANIMAL CELLS; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; PATHOLOGICAL CHANGES; PHAGOCYTES; RADIATIONS; SOMATIC CELLS; SYMPTOMS