Radiotherapeutically induced chromosome aberrations: Studies in biological dosimetry
Description
The yield of chromosome aberrations (dicentric chromosomes, ring chromosomes) induced in lymphocytes of four radiotherapy patients was determined. In each case this yield was drastically increased when compared with the spontaneous incidence, the dicentric frequencies increasing by the following factors: 604, 525, 600, and 725. With the aid of the dicentric yield obtained, the following equivalent whole body doses were estimated ( biological dosimetry ): 309, 286, 308, and 341 rd. Comparing the observed with the theoretical number of cells with 0, 1, 2, 3... dicentrics ( distribution analysis ), we found a highly significant departure from the Poisson distribution, as was to be expected after partial body irradiation. The distribution analysis seems principally suited to discriminate between partial and whole body irradiation. (orig.)
Abstract (German)
Bei vier therapeutisch bestrahlten Patienten wurde die Haeufigkeit von in den Lymphozyten induzierten Chromosomenaberrationen (dizentrische Chromosomen, Ringchromosomen) ermittelt. Sie war in allen vier Faellen stark erhoeht; bei den dizentrischen Chromosomen um das 604-, 525-, 600- und 725fache der Spontanrate. Mit Hilfe der fuer dizentrische Chromosomen gefundenen Haeufigkeiten wurden die folgenden Ganzkoerperaequivalentdosen erhalten ( biologische Dosimetrie ): 309, 286, 308 und 341 rd. Ein Vergleich der beobachteten mit der theoretischen Zahl der Zellen mit 0, 1, 2, 3... dizentrischen Chromosomen ( Verteilungsanalyse ) ergab die bei Teilkoerperbestrahlungen zu erwartende Abweichung von der Poisson-Verteilung. Die Verteilungsanalyse erscheint grundsaetzlich geeignet, zwischen Teil- und Ganzkoerperbestrahlung zu unterscheiden. (orig.)Additional details
Additional titles
- Original title (German)
- Strahlentherapeutisch induzierte Chromosomenaberrationen: Untersuchungen zur biologischen Dosimetrie
Publishing Information
- Journal Title
- Strahlentherapie
- Journal Volume
- 157
- Journal Issue
- 9
- Series
- Strahlentherapie.
- Journal Page Range
- 607-612
- ISSN
- 0039-2073
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 13671383
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE; S61: RADIATION PROTECTION AND DOSIMETRY;
- Descriptors DEI
- BIOLOGICAL DOSEMETERS; CHROMOSOMAL ABERRATIONS; DICENTRIC CHROMOSOMES; EARLY RADIATION EFFECTS; ELECTRIC POTENTIAL; ELECTRON BEAMS; FRACTIONATED IRRADIATION; GAMMA RADIATION; GAMMA SOURCES; HARD X RADIATION; LYMPHOCYTES; MEV RANGE 01-10; MEV RANGE 10-100; NEOPLASMS; PATIENTS; PHOTON BEAMS; RADIATION DOSE UNITS; RADIOTHERAPY; RING CHROMOSOMES; STATISTICS
- Descriptors DEC
- ANIMAL CELLS; BEAMS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY FLUIDS; CHROMOSOMES; CONNECTIVE TISSUE CELLS; DISEASES; DOSEMETERS; ELECTROMAGNETIC RADIATION; ENERGY RANGE; IONIZING RADIATIONS; IRRADIATION; LEPTON BEAMS; LEUKOCYTES; MATHEMATICS; MEASURING INSTRUMENTS; MEDICINE; MEV RANGE; MUTATIONS; PARTICLE BEAMS; RADIATION EFFECTS; RADIATION SOURCES; RADIATIONS; SOMATIC CELLS; THERAPY; UNITS; X RADIATION