Published January 1984 | Version v1
Journal article Metadata-only

Radiosensitivity of pluripotent stem cells determined by cloning in the irradiated mouse spleen

Creators

  • 1. Akademiya Meditsinskikh Nauk SSSR, Obninsk. Nauchno-Issledovatel'skij Inst. Meditsinskoj Radiologii

Description

It was shown that the dose-effect cunves describing the radiodensitivity of CFUC of the bone marrow irradiated in vitro (0.04-3.7 Gy) and treated with normal rabbit serum (NRS) and anti-mouse-brain serum tly(AMBS) has two different sloping portions indicating that two CFUc populations differing in radiosensitivity are present in the bone marrow D0 Was 0.93 Gy after irradiation with doses of 0.04-0.75 Gy and treatment with NRS, and 0.33 Gy after incubation of the bone marrow with AMBS. The addition of thymus cells ''strightened'' the dose-effect curve for the bone marrow treated with AMBS: in this case D0 was 1.81 Gy exceeding considerably the values of D0 for intact bone marrow. The CFUC population is suggested to be heterogeneous in radiosensitivity

Additional details

Additional titles

Original title (Russian)
Радиочувствительност' плюрипотентных стволовых клеток, определяемая клонированием в селезенке облученных мышей

Publishing Information

Journal Title
Radiobiologiya
Journal Volume
24
Journal Issue
1
Series
Radiobiologiya.
Journal Page Range
39-43
ISSN
0033-8192

INIS

Country of Publication
Russian Federation
Country of Input or Organization
USSR
INIS RN
15055908
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; BONE MARROW; CARBONIC ACID DERIVATIVES; CFU; DOSE-RESPONSE RELATIONSHIPS; GAMMA RADIATION; IN VITRO; IN VIVO; MICE; ORGANIC NITROGEN COMPOUNDS; RADIOSENSITIVITY; SPLEEN; STEM CELLS
Descriptors DEC
ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BODY; ELECTROMAGNETIC RADIATION; HEMATOPOIETIC SYSTEM; IONIZING RADIATIONS; MAMMALS; ORGANIC COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; TISSUES; VERTEBRATES

Optional Information

Notes
For English translation see the journal Radiobiology (Translation) (USA).