Published December 1993 | Version v1
Journal article Metadata-only

Synthesis of a [11C]methoxy derivative of α-dihydrotetrabenazine: a radioligand for studying the vesicular monoamine transporter

Creators

  • 1. Michigan Univ., Ann Arbor, MI (United States). Div. of Nuclear Medicine

Description

The synthesis of [11C]TBZOMe, a [11C]methoxy derivative at the 2-hydroxy position of α-dihydrotetrabenazine, was carried out by an O-[11C]methylation reaction. The product [11C]TBZOMe (100-200 mCi) was obtained in 15-40% radiochemical yield (corrected for decay) within 37 min, and in high specific activity (2000-2500 Ci/mmol) and radiochemical purity (>97%). [11C]TBZOMe is a potential new radioligand for studying the vesicular monoamine transporter using positron emission tomography. (Author)

Additional details

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
44
Journal Issue
12
Journal Page Range
p. 1487-1489.
ISSN
0969-8043
CODEN
ARISEF

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
25013905
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
AZINES; CARBON 11; CHEMICAL PREPARATION; LABELLING; LIGANDS; METHYLATION; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CHEMICAL REACTIONS; COMPUTERIZED TOMOGRAPHY; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; HETEROCYCLIC COMPOUNDS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS; TOMOGRAPHY