Survival of human osteosarcoma cells and normal human fibroblasts following alpha particle irradiation
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Description
Cell survival of human osteosarcoma cells in culture following alpha particle irradiation is reported here for the first time. The osteosarcoma cell line (TE-85) is found to be less sensitive to inactivation by 5.6 MeV alpha particles (LET 86 keV/μm) than normal diploid human fibroblasts (NFS). Values for the mean lethal doses were estimated to be 103 rads for the TE-85 cells compared with 68 rads for the NFS cultures irradiated under identical conditions. It is postulated that the aneuploidy of the tumor cells with increased DNA chromosomal material may confer a selective advantage for the survival of tumor cells relative to normal cells with diploid chromosomes
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Additional details
Publishing Information
- Imprint Title
- Radiological and Environmental Research Division annual report, July 1979-June 1980
- Journal Page Range
- p. 33-40.
- Report number
- ANL--80-115-Part2
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 12638015
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ALPHA PARTICLES; ANEUPLOIDY; BIOLOGICAL RADIATION EFFECTS; CELL KILLING; FIBROBLASTS; IN VITRO; LETHAL RADIATION DOSE; MEV RANGE 01-10; OSTEOSARCOMAS; SURVIVAL CURVES; TUMOR CELLS
- Descriptors DEC
- ANIMAL CELLS; BIOLOGICAL EFFECTS; CHARGED PARTICLES; CONNECTIVE TISSUE CELLS; DISEASES; ENERGY RANGE; HELIUM IONS; IONS; MEV RANGE; NEOPLASMS; PLOIDY; RADIATION DOSES; RADIATION EFFECTS; SARCOMAS; SKELETAL DISEASES; SOMATIC CELLS