Home brew technetium : clinical scale desktop plasma fusion neutron source to produce Tc99m as an alternative to industrial scale fission reactor sources

Full text: Tc-99m (decay product of Mo-99) accounts for ∼ 90% of world's production of radiopharmaceuticals. Recent unexpected shutdowns of two fission reactors and routine maintenance closures .e created a global shortage of Tc-99m, hence the large global effort to find alternative sources. This project aims to design and produce a novel prototype Mo-99/Tc-99m source. An operational desktop neutron source is available at the University of Sydney, employing a deuterium fusion-plasma to create 2.45 MeV neutrons. These neutrons will be used to activate Mo-98 thin an activation vessel. In one embodiment, the activation vessel contains an aqueous slurry or gel containing Mo-98 which converts to 0-99 upon activation. The decay product Tc-99m could then be milked, similar to existing Tc-99m generators. Monte Carlo will be :ed to assess yield versus size and geometry for various vessel designs. The neutron source filled with deuterium operating at 250 W, produces 3 x 106 neutrons continuously. The neutron flux can be increased ∼ 100-fold if the fill gas is 50% tritium and by another ∼ 100-1000-fold by increasing the power. This is being designed for local use, perhaps on the scale f one or a few hospitals, so the yield would not need to be industrial ;ale as with fission reactor sources. This device is low cost <$300 K) compared with cyclotrons and fission reactors.