Development of 188Re-Hynic-Lanreotide as radiopharmaceutical for cancer treatment
Creators
- SRIWIANG, W.1
- MINSAKORN, N.2
- SANGSURIYAN, J.2
- Thailand Institute of Nuclear Technology (Thailand)
- Ministry of Science and Technology (Thailand)
- Office of Atoms for Peace (Thailand)
- Electrticity Generating Authority of Thailand (Thailand)
- Nuclear Society of Thailand (Thailand)
- Department of Agriculture (Thailand)
- Hydro and Agro Informatics Institute (Thailand)
- Department of Livestock Development (Thailand)
- Nuclear Medicine Society of Thailand (Thailand)
- 1. Research and Development Section, Thailand Institute of Nuclear Technology, Bangkok (Thailand)
- 2. Isotope Production Center, Thailand Institute of Nuclear Technology, Bangkok (Thailand)
Description
Full text: Hynic ligand, which complexes with metal radionuclide in milder condition than other normal ligands, was conjugated with peptide, Lanreotide. The conjugated product was purified by HPLC and its concentration was estimated by UV-Vis spectrophotometer. Molecular weight of Hynic-Lanreotide was confirmed by mass spectrometer (TOF-MS) with M/Z at 1231. Labeling of Hynic-Lanreotide with Re-188 radionuclide was done by wet labeling to verify optimum condition. The optimum condition found was as follows; 20 mg coligand (tricine), 350 ?g reducing agent (SnCl2.2H2O) and 10 ?g Hynic-Lanreotide labeled with 3-10 mCi ReO-4 at 70 OC for 1 hour. The labeling yield was ranged between 60 and 70%. Further purification by solid phase extraction (C-18 sep pak?) increased radiochemical purity to 85-90%
Availability note (English)
Available in abstract form only, full text entered in this record. Available from Thailand Institute of Nuclear Technology, Bangkok (Thailand)Additional details
Publishing Information
- Imprint Pagination
- 11 p.
- Report number
- INIS-TH--173
Conference
- Title
- 10. Conference on Nuclear Science and Technology
- Dates
- 16-17 Aug 2007
- Place
- Bangkok (Thailand)
INIS
- Country of Publication
- Thailand
- Country of Input or Organization
- Thailand
- INIS RN
- 40048215
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Conference, Numerical Data, Non-conventional Literature
- Descriptors DEI
- EXPERIMENTAL DATA; LABELLED COMPOUNDS; LABELLING; LIGANDS; NEOPLASMS; RADIOCHEMICAL ANALYSIS; RADIOPHARMACEUTICALS; RHENIUM 188
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHEMICAL ANALYSIS; DATA; DISEASES; DRUGS; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; INFORMATION; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; NUMERICAL DATA; ODD-ODD NUCLEI; QUANTITATIVE CHEMICAL ANALYSIS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RHENIUM ISOTOPES
Optional Information
- Secondary number(s)
- NST--10-MS05