Published 1988
| Version v1
Journal article
Albumin binding of paramagnetic hepatobiliary contrast agents: enhancement of outer sphere relaxivity
- 1. Massachusetts General Hospital, Boston (USA). Radiology Dept.
- 2. Massachusetts General Hospital, Boston (USA)
Description
The present study examines the binding of several recently developed hepatobiliary MR contrast agents including iron(III) ethylenebis-(2-hydroxy-phenylglycine) (Fe(EHPG)-), 5-substituted EHPG derivatives, and iron(III) bis(2-hydroxy-benzyl)-ethylenediaminediacetate (Fe(HBED)-) to human serum albumin (HSA). Our primary purpose was to use this model system to study the effect of non-covalent protein binding on the relaxivities of these iron complexes. (author)
Additional details
Publishing Information
- Journal Title
- Nucl. Med. Biol.
- Journal Volume
- 15
- Journal Issue
- 1
- Series
- Nucl. Med. Biol.
- Journal Page Range
- 45-46
- ISSN
- 0883-2897
- CODEN
- NMBIE
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 19058705
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ALBUMINS; BILIARY TRACT; CONTRAST MEDIA; IRON COMPLEXES; LIGANDS; LIVER; NMR IMAGING; RELAXATION TIME
- Descriptors DEC
- BODY; COMPLEXES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; GLANDS; ORGANIC COMPOUNDS; ORGANS; PROTEINS; TRANSITION ELEMENT COMPLEXES