Published November 1, 1984
| Version v1
Journal article
Chromatographic and biological comparison of sup(99m)Tc-DMSA prepared by direct labelling and ligand exchange reaction
Description
Sup(99m)Tc-dimercaptosuccinic acid (DMSA) is one of the most favourable agents used for renal scintigraphy. This radiopharmaceutical was prepared in two different ways: by direct labelling of tin(II)-dimercaptosuccinic acid and by ligand exchange reaction from sup(99m)Tc-gluconate at tracer concentration of technetium under acidic condition. The complexes formed were compared using paper chromatography, thin layer chromatography, gel filtration and electrophoresis. Their biodistribution was studied on rats. (author)
Additional details
Publishing Information
- Journal Title
- J. Radioanal. Nucl. Chem.
- Journal Volume
- 87
- Journal Issue
- 5
- Series
- J. Radioanal. Nucl. Chem. ;Letters.
- Journal Page Range
- 301-310
- ISSN
- 0236-5731
INIS
- Country of Publication
- Hungary
- Country of Input or Organization
- Hungary
- INIS RN
- 16033657
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOCHEMICAL REACTION KINETICS; CHEMICAL PREPARATION; CHROMATOGRAPHY; DISTRIBUTION; ELECTROPHORESIS; ISOTOPIC EXCHANGE; LABELLING; LIGANDS; ORGANIC SULFUR COMPOUNDS; ORGANS; RADIOPHARMACEUTICALS; TECHNETIUM COMPLEXES; TECHNETIUM 99; TIN COMPLEXES
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COMPLEXES; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; REACTION KINETICS; SEPARATION PROCESSES; SYNTHESIS; TECHNETIUM ISOTOPES; TRANSITION ELEMENT COMPLEXES; YEARS LIVING RADIOISOTOPES
Optional Information
- Notes
- 13 refs.; 5 figs.