An assay of biological dosimetry from the changed number of lymphocytes and hypersegmented neutrophiles evaluated by means of statistical decision method

The paper presented deals with the statistical utilization of changes in lymphocyte and hypersegmented neutrophiles counts in pheripheral blood after irradiation for the biological detection of ionizing radiation. Both parameters are in a good correlation during simultaneous evaluation of their changes, and they fail during evaluation in various time intervals after irradiation. The changes of the two hematological parameters after irradiation, lymphopenia and hypersegmentation of cellular nuclei of granulocytes were therefore utilized. The changes under examination were elaborated in the computer and evaluated by a method of regression classification and by discriminatory analysis. This analytical way enables a new conception in the evaluation of individual hematological post-irradiation changes. This study is being continued along several lines. On the one hand, further statistical methods of making the results more precise will be used; on the other hand, other laboratory animals will be tested as well. Last but not least, the best statistical method will be used in an attempt to biologically detect the changes after therapeutical irradiation in man. (orig.)