PET imaging agent of 18F labelled non-natrual animo acid

Along with the rapid development of PET and PET-CT technologies, the application of 18F- labelled radiopharmaceuticals is more and more widespread in clinic. 18F has predominant physical features with long half-life(110min). Also, the chemical nature of 18F is similar to that of hydrogen, it can't change the labelled molecular's character obviously. Therefore, the 18F is the best choice of radionuclide used in PET. However, natural animo acid has the character of metabolizing easily and complexly, the studies in non- natrual animo acid have increased gradually such as tyrosine derivatives, phenylalanine derivatives, proline derivatives, methionine derivatives, and so on. The article summarizes the 18F-labelled non-natural amino acids and their derivatives studied in recent years. (authors)