Heavy-charged-particle irradiation of Phase I and II patients at the Bevalac

Patients entered in this study are treated with helium, carbon, neon, and silicon heavy particles as part of Phase I-II trials of the following target sites: RBE studies (skin and subcutaneous metastases); malignant glioma of the brain; locally advanced carcinomas of the pancreas, biliary tract, and stomach; selected, advanced head and neck tumors; locally advanced soft tissue sarcomata; locally advanced carcinomas of the lung; and locally advanced carcinoma of the prostate. Most of the required Phase I-II studies for these sites have been completed for neon particles, although much remains to be accumulated for silicon ions