Published March 1993
| Version v1
Journal article
Sublethal damage and DNA double strand breaks have similar RBE-LET relationships: evidence and implications
Description
An important problem with the hypothesis that DNA strand breaks are the primary lesions causing cell reproductive death is the weak dependence of the induction of double strand breaks on LET in contrast with the strong dependence of cell inactivation on LET. The author analyses this problem and examines RBE-LET relationships for DNA double strand breaks and sub-lethal damage and discusses linear and quadratic terms in dose-effect relations for cell reproductive death. (Author)
Additional details
Publishing Information
- Journal Title
- International Journal of Radiation Biology
- Journal Volume
- 63
- Journal Issue
- 3
- Journal Page Range
- p. 325-330.
- ISSN
- 0955-3002
- CODEN
- IJRBE7
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 24053332
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ANIMAL CELLS; BIOLOGICAL RADIATION EFFECTS; CELL KILLING; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIPS; LET; RADIATION QUALITY; RBE; STRAND BREAKS; SUBLETHAL IRRADIATION
- Descriptors DEC
- BIOLOGICAL EFFECTS; ENERGY TRANSFER; IRRADIATION; RADIATION EFFECTS