Published March 1984
| Version v1
Journal article
The toxicity of tritium: the effects of tritiated amino-acids on preimplanted mouse embryos
- 1. Commission of the European Communities, Ispra (Italy). Joint Research Centre
- 2. Trinity Coll., Dublin (Ireland). Dept. of Biochemistry
Description
The effects of tritiated amino-acids, arginine, lysine, histidine and aspartic acid on the growth and development of two-cell mouse embryos, cultured in vitro, were investigated. The LD50 for the dibasic amino acids, measured on the third day of growth, ranged from 30 to 130 nCi/ml. This was compared with the DNA precursor, thymidine, for which the LD50 was 80 nCi/ml. (author)
Additional details
Publishing Information
- Journal Title
- Int. J. Radiat. Biol. Relat. Stud. Phys., Chem. Med.
- Journal Volume
- 45
- Journal Issue
- 3
- Series
- Int. J. Radiat. Biol. Relat. Stud. Phys., Chem. Med.
- Journal Page Range
- 245-250
- ISSN
- 0020-7616
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 15055963
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ARGININE; ASPARTIC ACID; BIOLOGICAL RADIATION EFFECTS; DOSE-RESPONSE RELATIONSHIPS; EMBRYOS; HISTIDINE; LETHAL RADIATION DOSE; LYSINE; MICE; THYMIDINE; TRITIUM; TRITIUM COMPOUNDS
- Descriptors DEC
- AMINO ACIDS; ANIMALS; AZINES; AZOLES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; CARBOXYLIC ACIDS; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; HYDROGEN ISOTOPES; IMIDAZOLES; ISOTOPES; LIGHT NUCLEI; MAMMALS; NUCLEI; NUCLEOSIDES; NUCLEOTIDES; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIATION DOSES; RADIATION EFFECTS; RADIOISOTOPES; RIBOSIDES; RODENTS; VERTEBRATES; YEARS LIVING RADIOISOTOPES