Published 1988
| Version v1
Journal article
Synthesis of [18F]GBR13119, a presynaptic dopamine uptake antagonist
Description
[18F]GBR 13119 (1-[(4-[18F]fluorophenyl)-(phenyl)methoxy]ethyl-4-(3-phenylpropyl) piperazine) has been prepared in no carrier added form by a four-step synthesis from [18F]fluoride. Isolated yields are 7-10% (uncorrected) in a synthesis time of 120 min. The product is obtained in high specific activity (> 1000 Ci/mmol) and high radiochemical purity (>99%) without chromatographic purification. Small amounts of chemical impurity, identified as the nitro-substituted analog by independent synthesis, can be removed by HPLC. [18F]GBR13119 is proposed as a new radiotracer for the presynaptic dopamine uptake system. (author)
Additional details
Publishing Information
- Journal Title
- Appl. Radiat. Isot.
- Journal Volume
- 39
- Journal Issue
- 4
- Series
- Appl. Radiat. Isot.
- Journal Page Range
- 279-282
- CODEN
- ARISE
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 19062103
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CHEMICAL PREPARATION; DOPAMINE; FLUORINE 18; IMPURITIES; ORGANIC FLUORINE COMPOUNDS; PIPERAZINES; RADIOPHARMACEUTICALS
- Descriptors DEC
- AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENT; AZINES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARDIOTONICS; CARDIOVASCULAR AGENTS; DRUGS; FLUORINE ISOTOPES; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NEUROREGULATORS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PHENOLS; POLYPHENOLS; PYRAZINES; RADIOACTIVE MATERIALS; RADIOISOTOPES; STEROIDS; SYMPATHOMIMETICS; SYNTHESIS