Published 2006 | Version v1
Journal article Metadata-only

Synthesis of 2-[18F]fluorine-L-tyrosine and comparative investigation of it accumulation in neoplasm rat gliomas 35 and in inducted center of inflammation in laboratory animals

Creators

  • 1. RAN, Inst. Mozga Cheloveka, Sankt-Peterburg (Russian Federation)
  • 2. Tsentral'nyj Nauchno-Issledovatel'skij Rentgenoradiologicheskij Inst., Sankt-Peterburg (Russian Federation)
  • 3. RAN, Inst. Ehlementoorganicheskikh Soedinenij im. A.N. Nesmeyanova, Moscow (Russian Federation)

Description

Comparative investigation of 2-[18F]fluorine-L-tyrosine accumulation in neoplasms (rat gliomas 35) and in sterile inflammation center is done. For 2-[18F]fluorine-L-tyrosine preparation the method of interphase chiral catalysis, proposed earlier, is used. Obtained data show that the method of positron computed tomography with two radiotracers (2-[18F]fluorine-L-tyrosine and 2-[18F]-2-desoxy-D-glucose) permits to realize differentiated diagnostics of neoplasms and inflammation centre

Abstract (Russian)

Проведено сравнительное исследование накопления 2-[18F]фтор-L-тирозина в опухоли (крысиная глиома 35) и стерильном абсцессе. Для получения 2-[18F]фтор-L-тирозина использовали предложенный ранее метод межфазного хирального катализа. Полученные данные показывают, что использование двух радиотрейсеров (2-[18F]фтор-L-тирозина и 2-[18F]фтор-2-дезокси-D-глюкозы) позволит осуществить дифференцированную диагностику опухоли и очага воспаления методом позитронной компьютерной томографии

Additional details

Additional titles

Original title (Russian)
Синтез 2-[

Publishing Information

Journal Title
Radiokhimiya
Journal Volume
48
Journal Issue
5
Journal Page Range
p. 458-462
ISSN
0033-8311
CODEN
RADKAU

INIS

Country of Publication
Russian Federation
Country of Input or Organization
Russian Federation
INIS RN
38038653
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BIOLOGICAL LOCALIZATION; CHEMICAL PREPARATION; CHEMICAL REACTION YIELD; FLUORINE 18; GLIOMAS; LABELLED COMPOUNDS; ORGANIC FLUORINE COMPOUNDS; POSITRON COMPUTED TOMOGRAPHY; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; RATS; TYROSINE
Descriptors DEC
AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROXY ACIDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MATERIALS; NANOSECONDS LIVING RADIOISOTOPES; NEOPLASMS; NERVOUS SYSTEM DISEASES; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; SYNTHESIS; TOMOGRAPHY; VERTEBRATES; YIELDS

Optional Information

Notes
16 refs., 4 figs., 1 tab.