Published June 1986
| Version v1
Journal article
Liver distribution of copper and 99Mo in sheep following intravenous administration of copper sulfate and [99Mo]-tetrathiomolybdate
Creators
- 1. Ontario Cancer Inst., Toronto, ON (Canada)
- 2. Agriculture Canada, Ottawa, ON (Canada). Animal Research Centre
Description
The effect of a single intravenous dose of 0, 50 or 100 mg molybdenum (Mo) as [99Mo] labelled sodium tetrathiomolybdate (Na2MoS4) on the subcellular distribution of copper (Cu) in the liver was studied in three groups of four sheep. The sheep received a 35-mg intravenous dose of Cu 20 h prior, and were killed 24 h after the dosing with mo. Subcellular fractionation of liver homogenates revealed that MoS42- may react with Cu in the nuclear (lysosomal) fraction. (author). 10 refs., 1 tab
Additional details
Publishing Information
- Journal Title
- Canadian Journal of Animal Science
- Journal Volume
- 66
- Journal Page Range
- p. 563-565.
- ISSN
- 0008-3984
- CODEN
- CNJNAT
INIS
- Country of Publication
- Canada
- Country of Input or Organization
- Canada
- INIS RN
- 27056051
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BIOLOGICAL LOCALIZATION; COPPER; COPPER SULFATES; INTRAVENOUS INJECTION; LIVER; LYSOSOMES; MOLYBDENUM 99; SHEEP; SUBCELLULAR DISTRIBUTION; TOXICITY
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CELL CONSTITUENTS; COPPER COMPOUNDS; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DISTRIBUTION; DOMESTIC ANIMALS; ELEMENTS; EVEN-ODD NUCLEI; GLANDS; GOLGI COMPLEXES; INJECTION; INTAKE; INTERMEDIATE MASS NUCLEI; ISOTOPES; MAMMALS; METALS; MOLYBDENUM ISOTOPES; NUCLEI; ORGANS; OXYGEN COMPOUNDS; RADIOISOTOPES; RUMINANTS; SULFATES; SULFUR COMPOUNDS; TRANSITION ELEMENT COMPOUNDS; TRANSITION ELEMENTS; VERTEBRATES