Published 1989 | Version v1
Journal article Metadata-only

The effect of indomethacin on nucleic acids in blood, hemopoietic and lymphoid tissues in continuously irradiated rats

Creators

  • 1. Univerzita P.J. Safarika, Kosice (Czechoslovakia). Katedra Vseobecnej Biologie

Description

The effect of indomethacin - a nonsteroid antiinflammatory drug with potential antitumor activity - on the development of radiation-induced changes was followed in blood, bone marrow, spleen, thymus and testes of rats. Indomethacin administered in drinking water (0.7-1.0 mg/kg per day) during a continuous 7-day irradiation with gamma rays (dose rate of 2.055 Gy/day, total accumulated dose of 14.385 Gy) caused a higher and more rapid incorporation of 3H-thymidine into blood DNA and an increase in blood RNA concentration. The results suggest some stimulation of hemopoiesis recovery by indomethacin treatment in continuously irradiated rats. (author). 2 figs., 3 tabs., 12 refs

Additional details

Publishing Information

Journal Title
Neoplasma
Journal Volume
36
Journal Issue
5
Series
Neoplasma.
Journal Page Range
541-547
ISSN
0028-2685
CODEN
NEOLA

INIS

Country of Publication
Slovakia
Country of Input or Organization
Serbia and Montenegro
INIS RN
21013948
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BLOOD; BLOOD FORMATION; BONE MARROW; CHRONIC IRRADIATION; DNA; DRINKING WATER; DRUGS; GAMMA RADIATION; INFLAMMATION; LEUKOCYTES; QUANTITY RATIO; RATS; RESPONSE MODIFYING FACTORS; RNA; SPLEEN; TESTES; THYMIDINE; THYMUS; TRITIUM COMPOUNDS
Descriptors DEC
ANIMALS; AZINES; BIOLOGICAL MATERIALS; BLOOD CELLS; BODY; BODY FLUIDS; CHRONIC EXPOSURE; DISEASES; ELECTROMAGNETIC RADIATION; GONADS; HEMATOPOIETIC SYSTEM; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; IONIZING RADIATIONS; IRRADIATION; LYMPHATIC SYSTEM; MALE GENITALS; MAMMALS; MATERIALS; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; OXYGEN COMPOUNDS; PATHOLOGICAL CHANGES; POLAR SOLVENTS; PYRIMIDINES; RADIATIONS; RIBOSIDES; RODENTS; SOLVENTS; TISSUES; VERTEBRATES; WATER