Published March 1, 1979 | Version v1
Journal article Metadata-only

Suppression of leukocyte inhibitory factor (LIF) production and [3H]thymidine incorporation by concanavalin A-activated mononuclear cells

Creators

  • 1. Univ. of Witwatersrand, Johannesburg, South Africa

Description

The capacity of human mononuclear (MN) cells pretreated with concanavalin A (Con A) to suppress the activity of fresh phytohemagglutinin (PHA)-pulsed mononuclear cells was assessed. Con A-pretreated MN cells suppressed leukocyte inhibitory factor (LIF) activity in supernatants of PHA-pulsed cell cultures and [3H]thymidine incorporation by these cells. Suppression was obtained in both allogeneic and autologous systems with mitomycin-treated, irradiated, or untreated Con A-induced cells. Lymphocytes from two patients that, following treatment with Con A, did not suppress mitogen-induced proliferative response of normal cells also did not suppress LIF production

Additional details

Publishing Information

Journal Title
Cell. Immunol.
Journal Volume
43
Journal Issue
1
Series
Cell. Immunol.
Journal Page Range
41-47
ISSN
0008-8749

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
10472912
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Numerical Data
Descriptors DEI
BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; EXPERIMENTAL DATA; GLOBULINS; IMMUNOSUPPRESSION; ISOLATED VALUES; LEUKOCYTES; MITOMYCIN; PATIENTS; PHYTOHEMAGGLUTININ; THYMIDINE; TRITIUM
Descriptors DEC
AGGLUTININS; ANTIBIOTICS; ANTIMITOTIC DRUGS; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOHYDRATES; DATA; DATA FORMS; DRUGS; HEMAGGLUTININS; HETEROCYCLIC COMPOUNDS; HYDROGEN ISOTOPES; INFORMATION; ISOTOPES; LIGHT NUCLEI; MUCOPROTEINS; NUCLEI; NUCLEOSIDES; NUCLEOTIDES; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; POLYSACCHARIDES; PROTEINS; PYRIMIDINES; RADIATION EFFECTS; RADIOISOTOPES; RIBOSIDES; SACCHARIDES; YEARS LIVING RADIOISOTOPES