Published October 27, 2021 | Version v1
Journal article Metadata-only

Analysis of whole-blood antioxidant capacity after chronic and localized irradiation using the i-STrap method

Creators

  • 1. Health and Medical Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki (Japan)
  • 2. Course of Radiological Technology, Health Sciences, Tohoku University Graduate School of Medicine, Sendai, Miyagi (Japan)
  • 3. Department of Occupational and Community Health Nursing, School of Health Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Fukuoka (Japan)
  • 4. Department of Radiobiology and Hygiene Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Fukuoka (Japan)

Description

Ionizing radiation exposure affects the redox state in vivo. Recently, whole-blood antioxidant capacity (WBAC) has been reported to decrease in a dose-dependent manner after acute total body irradiation (TBI). However, changes in WBAC after localized and chronic irradiations have not been reported. This study analyzed changes to WBAC in mice after either localized irradiation (irradiation of the left hind leg only) or chronic TBI using the i-STrap method. Leg-localized irradiation exerted limited effects on WBAC, while WBAC decreased in a dose rate-dependent manner after TBI. Further, the WBAC reached the minimum value in a shorter period at a smaller dose rate. Our results suggest that changes in WBAC do not directly reflect absorbed dose, but may reflect radiation-induced biological damage at the systemic level. This study will contribute to the understanding of radiation-induced injuries and diseases, and will facilitate the establishment of biomarkers for radiation exposure.

Availability note (English)

Available from http://dx.doi.org/10.1093/jrr/rrab099; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776686

Additional details

Identifiers

URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776686; https://creativecommons.org/licenses/by/4.0/;
DOI
10.1093/jrr/rrab099;

Publishing Information

Journal Title
Journal of Radiation Research
Journal Volume
63
Journal Issue
1
Journal Page Range
p. 30-35
ISSN
0449-3060

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
54111719
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ANTIOXIDANTS; BIOLOGICAL MARKERS; BLOOD CELLS; CHRONIC IRRADIATION; GY RANGE 01-10; LEGS; LOCAL IRRADIATION; LOCAL RADIATION EFFECTS; MICE; WHOLE-BODY IRRADIATION
Descriptors DEC
ABSORBED DOSE RANGE; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BODY; BODY FLUIDS; CHRONIC EXPOSURE; EXTERNAL IRRADIATION; GY RANGE; IRRADIATION; LIMBS; MAMMALS; MATERIALS; RADIATION DOSE RANGES; RADIATION EFFECTS; RODENTS; VERTEBRATES

Optional Information

Copyright
Copyright (c) The Author(s) 2021. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.
Notes
PMCID: PMC8776686; PMID: 34718686; PMID: 34718686; PUBLISHER-ID: rrab099; OAI: oai:pubmedcentral.nih.gov:8776686