Published January 20, 1984 | Version v1
Journal article Metadata-only

External imaging of cerebral muscarinic acetylcholine receptors

Creators

  • 1. George Washington Univ. Medical Center, Washington, DC

Description

A radioiodinated ligand that binds to muscarinic acetylcholine receptors was shown to distribute in the brain by a receptor-mediated process. With single-photon-emission imaging techniques, radioactivity was detected in the cerebrum but not in the cerebellum, whereas with a flow-limited radiotracer, radioactivity was detected in cerebrum and cerebellum. Single-photon-emission computed tomography showed good definition of the caudate putamen and cortex in man

Additional details

Publishing Information

Journal Title
Science (Washington, D.C.)
Journal Volume
223
Series
Science (Washington, D.C.).
Journal Page Range
291-292
ISSN
0036-8075

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
16054270
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ACETYLCHOLINE; BIOCHEMICAL REACTION KINETICS; BIOLOGICAL LOCALIZATION; BRAIN; COMPARATIVE EVALUATIONS; DISTRIBUTION; IODINE 125; LIGANDS; RECEPTORS; SINGLE PHOTON ECT; TISSUES; TRACER TECHNIQUES
Descriptors DEC
AMINES; AUTONOMIC NERVOUS SYSTEM AGENT; BETA DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; ESTERS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; KINETICS; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PARASYMPATHOMIMETICS; QUATERNARY COMPOUNDS; RADIOISOTOPES; REACTION KINETICS; TOMOGRAPHY