Radiochemical quality control of kits labelled with Tc-99m produced at IPEN-CNEN/SP

The radiopharmaceuticals labelled with Tc-99m are routinely used in Nuclear Medicine Laboratories. A large number of these employ tin (II) reagents to reduce Tc (pertechnetate-VII) to a lower valence state thereby making it more able to complex forming reactions. The miniaturized chromatography system of Tc-99m labelled compounds using Whatman 3MM (8 x 1 cm) as a support and 30% NaC1: 0,9% 'NaC1: 85% MeOH and acetone as a solvent permits to assay the radiochemical purity in a few minutes after preparation. In addition this method introduced in routine work not only determines Tc-99m (pertechnetate) but also determines reduced Tc - 99m unbound to the radiopharmaceuticals (hydrolyzed reduced Tc-99m). The lyophilized kits for labelling with Tc-99m produced at IPEN-CNEN/SP are: MDP, DTPA, HSA, GHA, HIDA, Pyro, MAA, MIAA, Sulfur Colloid, Dextran-500, Sn.Cit. and Phytate. Radiochemical quality control of these kits were performed at the first day of preparation and during 12 months for determining' their validity for use. All preparation showed high yield of labelling (95-99%) during this period of time. (author)