Published December 1986
| Version v1
Report
Effect of irradiation on unscheduled DNA synthesis induced by 4-nitroquinoline in tracheal epithelium of rats
Creators
Description
Unscheduled DNA synthesis (UDS) was determined in rat epithelium by autoradiographic techniques to determine the influence of prior irradiation on the ability of the cells to repair mutagenic damage induced by 4-nitroquionoline (4NQO). UDS was stimulated by in vitro exposure to 4NPO. However, prior whole-body irradiation of rats with either 50 or 300 rad did not alter the UDS induced by 4NQO. The results of this study do not support the hypothesis that irradiation can induce DNA repair enzymes in respiratory tract epithelium. 5 references, 3 figures
Additional details
Publishing Information
- Imprint Title
- Inhalation Toxicology Research Institute: Annual report, October 1, 1985 through September 30, 1986
- Journal Page Range
- p. 346-349.
- Report number
- LMF--115
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 19001372
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S61: RADIATION PROTECTION AND DOSIMETRY;
- Resource subtype / Literary indicator
- Numerical Data, Non-conventional Literature
- Descriptors DEI
- AROMATICS; DNA REPLICATION; EPITHELIUM; EXPERIMENTAL DATA; GENETIC EFFECTS; GENETIC RADIATION EFFECTS; NITRO COMPOUNDS; QUINOLINES; RATS; TRACHEA; WHOLE-BODY IRRADIATION
- Descriptors DEC
- ANIMALS; AZINES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DATA; EXTERNAL IRRADIATION; HETEROCYCLIC COMPOUNDS; INFORMATION; IRRADIATION; MAMMALS; NUCLEIC ACID REPLICATION; NUMERICAL DATA; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIDINES; RADIATION EFFECTS; RESPIRATORY SYSTEM; RODENTS; TISSUES; VERTEBRATES